18227 Atlanta middle-school students join Wisconsin peers at science camp This summer, there's no cooler place to be than in the lab for two dozen scientifically minded middle-school students. This summer, there's no cooler place to be than in the lab for two dozen scientifically minded middle-school students. The students, from the innovative <a href="http://www.ronclarkacademy.com/ ">Ron Clark Academy</a> in Atlanta, arrived in Madison July 12 for a stem cell science camp that spans four days. The Georgia middle-school students are being paired with students from the University of Wisconsin-Madison School of Education's <a href="http://www.peopleprogram.wisc.edu/">Pre-College Enrichment Opportunity Program for Learning Excellence</a> (PEOPLE), which also works to advance academic achievement among students of color and from families with low incomes. Organized by the <a href="http://discovery.wisc.edu/morgridge">Morgridge Institute for Research</a>, a private, nonprofit biomedical research institute affiliated with UW-Madison, the Generation Acceleration stem cell science camp aims to introduce diverse middle-school students from challenging backgrounds to a variety of careers in the rapidly growing field of regenerative biology. The students will work side by side with top university and Morgridge Institute stem cell researchers to learn about nourishing and culturing the blank slate cells into specialized heart muscle cells and neural cells, among other activities. "We're thrilled to welcome the Ron Clark Academy students and the PEOPLE Program students will help them feel right at home as they work together in the lab and experience life on campus," says Rupa Shevde, director of outreach experiences for the Morgridge Institute for Research. "Middle school is a critical time for students, and research has shown that if you can excite them about science, they are more likely to pursue a career in science, technology or engineering. Knowledge empowers them and with this kind experience on campus, it's our hope they will be more likely to choose the kinds of high-school classes they need to be prepared for college and beyond." Kim Bearden, co-founder and executive director of the Ron Clark Academy, says the trip to Wisconsin caps months of preparation for the students. The Ron Clark Academy combines focused classroom study with independent learning and enrichment programs to help students gain the skills, self-confidence and self-discipline they need to achieve their potential. "This is a wonderful opportunity for our students to experience what it's like to be on a college campus and learn more about cutting-edge science from leaders in their respective fields," Bearden says. "Through their hard work and individual achievement, these students have really earned the honor of participating and it's a pleasure to partner with the Morgridge Institute and the PEOPLE program on this project." At the same time, working with students from the Ron Clark Academy offers an exciting opportunity for the PEOPLE scholars, says PEOPLE director Jacqueline DeWalt. "It broadens their perspective on how many other college-bound and science-savvy students there are across the country," says DeWalt. "In addition to exposure to potentially life-changing science and research, they are meeting students who could be their future academic and professional colleagues. This partnership also reinforces their home state of Wisconsin's role as the epicenter of emerging scientific development and job markets." In addition to their work in the lab during the week, the students will be treated to a Wonders of Physics show and a special Chocolate 101 class. Fri Jul 16 00:00:00 -0500 2010 Wed Jul 14 14:11:00 -0500 2010

Wed Jul 14 14:12:29 -0500 2010

17758 Gift of $16 million pharmaceutical facility benefits Morgridge Institute Mentor Worldwide LLC's donation of a $16 million manufacturing facility to the new Morgridge Institute for Research at the University of Wisconsin-Madison will help fuel the nonprofit's mission of accelerating biomedical discoveries to delivery as treatments and cures. Mentor Worldwide LLC's donation of a $16 million manufacturing facility to the new <a href="http://www.discovery.wisc.edu/morgridge/">Morgridge Institute for Research</a> at the University of Wisconsin-Madison will help fuel the nonprofit's mission of accelerating biomedical discoveries to delivery as treatments and cures. Sangtae "Sang" Kim, executive director of the private Morgridge Institute, said the 37,000-square-foot, state-of-the-art biomedical facility offers new and important resources for the institute and its scientists. The new facility is located on Madison's west side in University Research Park, the location of more than 100 companies employing about 3,500 people. Morgridge scientists, which include stem cell pioneer James Thomson, TomoTherapy founder T. Rock Mackie, and Howard Hughes Medical Investigator and virologist Paul Ahlquist, plan to collaborate frequently with biomedical and pharmaceutical companies in their efforts to efficiently transition drugs and medical devices into clinical testing and commercial production. "This generous gift from Mentor is remarkable as it offers our young institute first-class finished space and resources on the west side of Madison, even before our primary and central location on campus has opened," says Kim. The Morgridge Institute, along with its twin public institute and a main floor Town Center welcoming all, will be housed in the new Wisconsin Institutes for Discovery. This facility, now under construction between University Avenue and Campus Drive, will open in December in the heart of the UW-Madison campus. AnnaMarie Daniels, vice president of Mentor Biologics, says, "We are pleased to make this donation to the Morgridge Institute for Research because we share a mutual goal of accelerating interdisciplinary biomedical research through collaboration between industry and academic-based organizations." Carl Gulbrandsen, chair of the Morgridge Institute's board of trustees and managing director of the Wisconsin Alumni Research Foundation, applauds the donation as an example of how industry and academic collaboration can foster the development of new discoveries to benefit society. "Our partnership with Mentor illustrates how ties between business and nonprofit organizations can advance human health," Gulbrandsen says. "This gift highlights that important work already is under way at the Morgridge Institute for Research and its potential for improving human health is recognized by research partners." According to Kim, "Morgridge scientists focused on regenerative biology, virology, medical devices, pharmaceutical informatics, and health education are already applying their research expertise to selected health challenges. We believe our interdisciplinary and targeted approach to research can yield new medical treatments, as well as life changing and saving health care products. The donation of this building will enhance our ability and flexibility to bring these discoveries to market.'' Designed to meet stringent requirements for pharmaceutical manufacturing, the facility combines flexible production space with an architectural promenade that allows visitors to view the manufacturing process. The building is LEED certified, meaning it has achieved a series of benchmarks in energy conservation and environmental sustainability. It currently is valued at $16 million. The Morgridge Institute for Research is made possible by funding from private donors, including John and Tashia Morgridge, whose generosity has helped launch the innovative, state-of-the-art Wisconsin Institutes for Discovery. More information is available at <a href="http://www.morgridgeinstitute.org">http://www.morgridgeinstitute.org</a>. Wed Mar 03 10:46:00 -0600 2010

Wed Mar 03 10:46:19 -0600 2010

17659 Morgridge Institute for Research announces scientific leadership team, research areas The Morgridge Institute for Research has finalized its inaugural team of top scientists selected to bring to life the institute's mission of accelerating discovery to delivery to improve human health. The <a href="http://www.discovery.wisc.edu/morgridge/">Morgridge Institute for Research</a>, the private side of the new interdisciplinary <a href="http://discovery.wisc.edu/discovery">Wisconsin Institutes for Discovery</a> at the University of Wisconsin-Madison, has finalized its inaugural team of top scientists selected to bring to life the institute's mission of accelerating discovery to delivery to improve human health. "We will focus world-class talent on advancing discoveries in five research challenge areas that have tremendous potential for improving the health of millions of people around the world," says Sangtae "Sang" Kim, executive director of the nonprofit interdisciplinary institute. "Our mission is to accelerate the ability to treat, cure or eradicate such devastating diseases as hepatitis C, cancer, diabetes and heart disease." <div id="story_quote_w9obFv9OtH" class="inline-content pull_quote right"> "Our mission is to accelerate the ability to treat, cure or eradicate such devastating diseases as hepatitis C, cancer, diabetes and heart disease." Sangtae Kim </div> The five areas selected for research are regenerative biology, which includes stem cell science; virology, the study of viruses; medical devices; pharmaceutical informatics, the use of information technology, statistics and mathematics to improve and speed drug development; and education research. In addition, Kim announced the nonprofit institute will launch programs to explore and promote core computational technology and scientific outreach. Seven UW-Madison researchers, who will recruit and hire top talent from around the world, have been approved by the institute's board of trustees to lead these research areas and programs at the new biomedical research organization: <ul> <li><a href="http://discovery.wisc.edu/home/morgridge/research/regenerative-biology/">James Thomson</a>, the stem cell pioneer named the first member of the Morgridge scientific leadership team in 2008 and an anatomy professor at the UW-Madison School of Medicine and Public Health, is directing the <a href="http://discovery.wisc.edu/home/morgridge/research/regenerative--biology/regenerative-biology-home.cmsx">regenerative biology</a> focus area.</li> <li><a href="http://www.mcardle.wisc.edu/faculty/bio/ahlquist_p.html">Paul Ahlquist</a>, Howard Hughes Medical Investigator and a UW-Madison professor of oncology at the School of Medicine and Public Health, molecular virology in the Graduate School and plant pathology in the College of Agricultural and Life Sciences, has been selected as the lead scientist of the <a href="http://discovery.wisc.edu/home/morgridge/research/virology-/virology-home.cmsx">virology</a> focus area.</li> <li><a href="http://www.medphysics.wisc.edu/medphys_docs/people/mackie/">Thomas "Rock" Mackie</a>, a UW-Madison professor of medical physics at the School of Medicine and Public Health and biomedical engineering in the College of Engineering, as well as the co-inventor, co-founder and chair of TomoTherapy Inc., will lead the <a href="http://discovery.wisc.edu/home/morgridge/research/medical-devices/medical-devices-home.cmsx">medical devices</a> focus area.</li> <li><a href="http://www.discovery.wisc.edu/home/morgridge/about-us/leadership/sang-kim/">Sangtae "Sang" Kim</a>, who has served as a professor of engineering at Purdue and engineering and computer science at UW-Madison, in executive positions at the National Science Foundation and within the pharmaceutical industry, and as an adviser to the Food and Drug Administration, will expand his executive director role to include principal investigator responsibility for the <a href="http://discovery.wisc.edu/home/morgridge/research/pharmaceutical-informatics/pharmaceutical-informatics-home.cmsx">pharmaceutical informatics</a> focus area.</li> <li><a href="http://www.wcer.wisc.edu/people/staff.php?sid=865">Susan Millar</a>, an anthropologist, senior scientist in the UW-Madison Wisconsin Center of Education Research, and a national leader in the evaluation of science education reform initiatives, will lead <a href="http://discovery.wisc.edu/home/morgridge/research/education-research/education-research-home.cmsx">education research</a> with a focus on improving health outcomes. Millar's role will bridge both Morgridge and UW-Madison's public Wisconsin Institute for Discovery as her research group will collaborate with scientists in both institutes to develop learning resources.</li> <li><a href="http://pages.cs.wisc.edu/~miron/">Miron Livny</a>, a UW-Madison professor of computer sciences in the College of Letters & Science and director of the UW-Madison Center for High Throughput Computing, will lead <a href="http://discovery.wisc.edu/home/morgridge/research/core-computational-technology/core-computational-technology-home.cmsx">core computational technology</a>. Livny also will serve both Morgridge and the Wisconsin Institute for Discovery by providing the advanced computing tools and infrastructure necessary to facilitate the leading edge work of scientists in both institutes.</li> <li><a href="http://stemcells.wisc.edu/faculty/shevde.html">Nirupama "Rupa" Shevde</a>, senior scientist and director of education and outreach at the WiCell Research Institute and a UW-Madison honorary associate/fellow in biochemistry at the College of Agricultural and Life Sciences, will expand her role to lead the development and operation of <a href="http://discovery.wisc.edu/home/morgridge/research/outreach-experiences/outreach-experiences-home.cmsx">Morgridge Outreach Experiences</a>, scientific learning programs directed at youth and the general public. </li> </ul> Kim noted that many members of his team have had a hand in the formation of the Morgridge Institute. Shortly after his appointment as executive director in September 2008, he began working with Thomson, and Ahlquist, Livny, Mackie and Millar as strategic consultants, to develop the mission, goals, operations and organizational structure of the new institute. All seven Morgridge scientific leaders will maintain their prior affiliations with UW-Madison and elsewhere. "Each member of the Morgridge scientific leadership team is stellar in his or her field," says Carl Gulbrandsen, chair of the Morgridge Institute for Research board of trustees and managing director of the <a href="http://www.warf.org/">Wisconsin Alumni Research Foundation</a> (WARF). "They understand the necessity of working across disciplines, out of their comfort zones and with increasingly powerful computational tools to achieve breakthrough discoveries. They are a winning team and poised to bring success to the Morgridge Institute." John Wiley, interim director of the public <a href="http://www.discovery.wisc.edu/wisconsin/">Wisconsin Institute for Discovery</a>, says, "Several of the WID and Morgridge researchers already knew each other well and were familiar with each others' work, and others are meeting for the first time. All are eager to get better acquainted and collaborate with their new colleagues at the institutes, as well as to create new and closer working relationships with a wide range of researchers and faculty on campus." While the innovative new facility for the twin Wisconsin Institutes for Discovery will not open until December, research at the Morgridge Institute has been under way in the Thomson lab since his appointment was announced two years ago. Likewise, the research and programs of the other scientists also have begun. All have had input into the design of their research "pods," located in "research neighborhoods" on the second, third and fourth floors and lower level of the facility. "I am delighted to see the Morgridge Institute off to such an exciting start," says UW-Madison Chancellor Biddy Martin. "Dr. Kim has assembled a remarkable team. With the scientific talent, research themes and challenge areas established for both sides of the Wisconsin Institutes for Discovery, we have new resources to ensure UW-Madison maintains its position as a top public research university, and Madison as a growing center for biotechnology." In addition to its top scientific team, the Morgridge Institute now employs approximately 30 other individuals, including research staff and development professionals who manage fundraising and donor relationships for the nonprofit institute. During the next year, the Morgridge Institute plans to hire approximately 100 additional employees. For more information, visit <a href="http://www.morgridgeinstitute.org">http://www.morgridgeinstitute.org</a>. Wed Feb 10 10:08:00 -0600 2010

Thu Feb 11 16:09:34 -0600 2010

17253 MathBio looks at ‘best picture’ If 2008’s inaugural MathBio Symposium was a big-picture look at collaboration, the focus of this year’s symposium is on the best picture. If 2008’s inaugural <a href="http://www.WiscMathBio.org">MathBio Symposium</a> was a big-picture look at collaboration, the focus of this year’s symposium is on the best picture. MathBio 2: Image, hosted by the <a href="http://www.discovery.wisc.edu/">Wisconsin Institutes for Discovery</a> and the <a href="http://www.grad.wisc.edu/">Graduate School</a> on Nov. 19 and 20 at the <a href="http://www.map.wisc.edu/?initObj=0139" title="View this building on the campus map">Fluno Center</a>, will highlight the need for interdisciplinary collaborative efforts to better understand, analyze, visualize and disseminate biological imaging data. Leading the list of keynote speakers is John Anderson, a senior scientist at Pixar Animation Studios and former UW-Madison atmospheric and oceanic science professor. Anderson, who founded the university’s Computational Sciences Program, has applied his expertise in fluid dynamics to create special effects and animation for films, and will discuss image visualization and analysis and how these approaches including visual abstraction can be applied in scientific imaging. Panels and presentations are structured to maximize the potential for fruitful cross-disciplinary discussion by inviting contributions from audience members and avoiding dips into jargon and minutia familiar only to experts in a single field. Maryellen L. Giger, a University of Chicago radiology professor and a leader in computer-aided diagnosis, and Robert F. Murphy, a computational biology professor at Carnegie Mellon University and a renowned expert in cell image analysis, are the other keynote speakers in a schedule that includes a number of UW-Madison life and physical science faculty and members of the Center for Humanities and the for Visual Culture Center. Wed Oct 21 09:31:00 -0500 2009

Wed Oct 21 09:32:52 -0500 2009

16776 Wisconsin Institutes for Discovery celebrate ‘topping out’ On May 26, the construction team of the new Wisconsin Institutes for Discovery held a “topping out” ceremony, traditional in the building industry for recognizing the construction milestone of placing and welding the last beam at the top of a building. On May 26, the <a href="http://wids.live.acumium.com/home/discovery/facility/construction-process/construction-team/">construction team</a> of the new <a href="http://discovery.wisc.edu">Wisconsin Institutes for Discovery</a> held a “topping out” ceremony, traditional in the building industry for recognizing the construction milestone of placing and welding the last beam at the top of a building. This event marks the completion of the external framework for the innovative facility, to be completed in December 2010. <div id="story_image_1403" class="inline-content photo right" style="width: 300px;"> <img src="http://www.news.wisc.edu/story_images/0000/1403/WIDs.jpg" alt=" " /> WARF Trustees John Morgridge, Joan Spero and Kathy Smith sign a beam before it is placed atop the new Wisconsin Institutes for Discovery at a ‘Topping Out’ ceremony held in May 2009. The facility, made possible by gifts from John and Tashia Morgridge, and WARF, will be completed in December 2010. <a href="http://wids.live.acumium.com/link.acux/fe8765c0-9cde-44c5-8b32-98cea5ab32fb/home/discovery/facility/construction-process/Topping%20Out%20Ceremony.cmsx">View and download more high-resolution photos</a> </div> The practice of “topping out” a new building has been traced to the ancient Scandinavian religious practice of placing a tree on the top of a new building to appease the tree-dwelling spirits of displaced ancestors. Members of the Findoff Mortenson construction crew signed the beam, painted white and adorned with a living tree, during a celebratory luncheon and then watched as the beam and tree were hoisted and welded into place atop the four-storey structure. Members of the Wisconsin Alumni Research Foundation (WARF) Board of Trustees participated in a similar ceremony (<a href="http://wids.live.acumium.com/link.acux/fe8765c0-9cde-44c5-8b32-98cea5ab32fb/home/discovery/facility/construction-process/Topping%20Out%20Ceremony.cmsx">see photos</a>) earlier in the month. Speakers shared some impressive facts about the facility with the approximate 200 workers who took part in the ceremony: • 98% of the materials removed during deconstruction of the prior buildings on the site has been recycled or reused • 564 miles of rebar have been used in construction of the facility • Each of the four floors (one below ground and three above) contains 2,200 yards of concrete and weighs 9 million pounds -- totaling nearly 9,000 yards and 36 million pounds of concrete • 2,200 pieces of structural steel and 210,000 man-hours have been used to build the facility • Worker safety is a top priority on the site with no current lost time due to injury • Construction of the project is on time and under budget Thu May 28 14:34:00 -0500 2009

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83 Kelly Janet jkelly@warf.org 16484 Recent sightings: Eyes on UW Photo: Two remote-controlled webcams, maintained by the Division of Information Technology and mounted on the roof of the Computer Sciences and Statistics building, document progress of different construction sites on campus. <div id="story_image_1233" class="inline-content photo span" style="width: 550px;"> <img src="http://www.news.wisc.edu/story_images/0000/1233/WID_webcam09_6101.jpg" alt=" " /> Two remote-controlled webcams, maintained by the Division of Information Technology and mounted on the roof of the Computer Sciences and Statistics building, document progress of different construction sites on campus. The top webcam records <a href="http://widmir-se.datn.wisc.edu/">Phase I construction of the Wisconsin Institutes for Discovery</a>, a location pictured at the bottom of photograph. The bottom webcam view documents the soon to start <a href="http://unionsouth1.doit.wisc.edu/">demolition and rebuilding of Union South</a>. Photo: <a href="mailto:photos@news.wisc.edu">Jeff Miller</a> </div> Mon Mar 30 13:25:00 -0500 2009

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WID_webcam09_6101-t.jpg false 241 160 12646 16473 Wisconsin, Morgridge scientists excise vector, exotic genes from induced stem cells A team of scientists from the Morgridge Institute for Research at the University of Wisconsin-Madison reports that it has created induced human pluripotent stem (iPS) cells completely free of viral vectors and exotic genes. A team of scientists from the <a href="http://www.morgridgeinstitute.org/">Morgridge Institute for Research</a> at the University of Wisconsin-Madison reports that it has created induced human pluripotent stem (iPS) cells completely free of viral vectors and exotic genes. By reprogramming skin cells to an embryonic state using a plasmid rather than a virus to ferry reprogramming genes into adult cells, the Wisconsin group's work removes a key safety concern about the potential use of iPS cells in therapeutic settings. The new method, which is reported in today's (March 26) online issue of the journal Science, also removes the exotic reprogramming genes from the iPS equation, as the plasmid and the genes it carries do not integrate into an induced cell's genome and can be screened out of subsequent generations of cells. Thus, cells made using the new method are completely free of any genetic artifacts that could compromise therapeutic safety or skew research results, according to the Science report. The new work was conducted in the laboratory of <a href="http://ink.primate.wisc.edu/~thomson/jamie.html">James Thomson</a>, the UW-Madison scientist who was the first to successfully culture human embryonic stem cells in 1998 and, in 2007, co-discovered a way to make human-induced pluripotent stem cells. Thomson, a professor in the UW-Madison School of Medicine and Public Health, is also the director of regenerative biology for the Morgridge Institute for Research, the private, nonprofit side of the new <a href="http://www.discovery.wisc.edu/">Wisconsin Institutes for Discovery</a> at UW-Madison. "We believe this is the first time human-induced pluripotent stem cells have been created that are completely free of vector and transgene sequences," says Thomson. The new study was led by geneticist Junying Yu, the Wisconsin researcher who, with Thomson, co-discovered a method for reprogramming adult skin cells to behave like embryonic stem cells, the master cells that arise at the earliest stages of development and that ultimately develop into all 220 cell types in the human body. While the methods first devised for reprogramming adult cells yielded embryonic-like cells, the process resulted in the permanent integration of both viral genes and the genes used for reprogramming into the genomes of the newly induced cells. Such genetic baggage posed safety concerns for potential therapies like cell transplants, and confounded work in the lab, as the introduced genes sometimes spurred mutations that interfered with the normal function of induced cells. The new work was accomplished using a plasmid, a circle of DNA, and cells from the foreskins of newborns. "The plasmids carry all the needed transgenes, but don't integrate into the host DNA, they just float around as episomes" in the cell, Thomson says. The plasmids replicate, but they do so somewhat inefficiently, Thomson explains, so that after they perform the job of reprogramming, they can subsequently be weeded out, leaving the induced cells free of any exotic genetic material. "Once the transgenes have done their job and are no longer needed, one can merely recover induced pluripotent stem cells that have lost their episomes." The resulting cells, says Thomson, are remarkably similar to embryonic stem cells and show the same capacity to proliferate indefinitely in culture and diversify into all the cell types of the human body. "The recent discovery that adult cells could be reprogrammed to iPS cells that resemble embryonic stem cells opened up tremendous potential for regenerative medicine," says Marion Zatz of the National Institute of Health's National Institute of General Medical Sciences, which partially funded the new work. "However, the early methods posed significant risks in using iPS cells in a clinical setting. This latest discovery by Thomson's group of a new method for generating iPS cells without inserting viral vectors into the cells' genetic material is a major advance toward safely reprogramming cells for clinical use." Thomson notes that researchers have developed other promising approaches using mouse cells, and previously had removed most of the vector and exogenous gene sequences from human-induced pluripotent stem cells. However, those efforts did not succeed in removing all of the genetic artifacts of reprogramming, which could still result in mutations in induced cells. "Given the rapid pace of the field, it won't be surprising if there are several alternative methods for producing vector and transgene free cells very soon," says Thomson. "However, it will be essential to determine which of these methods most consistently produces induced pluripotent stem cells with the fewest genetic abnormalities. Any problems would impact research, drug development and possible transplantation therapies." The new viral vector-free iPS cells will be available to researchers almost immediately through the International Stem Cell Bank at the <a href="http://www.wicell.org/index.php?option=com_content&task=category&sectionid=19&id=348&Itemid=262">WiCell Research Institute</a>, which also carries the four original iPS cell lines developed by the Thomson lab in 2007. Thu Mar 26 13:13:00 -0500 2009

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Cezar_stem_cell_cult07_3698-m-t.jpg false 75 75 5177 16436 For Kim, calculated risk is all in the game Like many overachievers, Sangtae Kim, who was named last fall to lead the Morgridge Institute for Research, is a calculated taker of risks. He knows chance when he sees it and, importantly, he knows how to size it up. Like many overachievers, <a href="http://www.morgridgeinstitute.org/news/index.php?category_id=3700&subcategory_id=5650">Sangtae Kim</a>, who was named last fall to lead the Morgridge Institute for Research, is a calculated taker of risks. He knows chance when he sees it and, importantly, he knows how to size it up. <div id="story_image_1207" class="inline-content photo right" style="width: 370px;"> <img src="http://www.news.wisc.edu/story_images/0000/1207/Kim_Sangtae_WID09_6033.jpg" alt=" " /> Sangtae Kim, director of the Morgridge Institute for Research, enjoys a rooftop vantage point to photograph Phase I construction of the Wisconsin Institutes for Discovery. Kim was standing on the roof of the Computer Sciences and Statistics building. Photo: <a href="mailto:photos@news.wisc.edu">Jeff Miller</a> </div> “The thing I remember about the corporate world, especially the (industrial) pharmaceutical world, is high risk-high reward,” says Kim, the former Purdue and Wisconsin engineering professor who was named last fall to lead the <a href="http://www.morgridgeinstitute.org/">Morgridge Institute for Research</a>, the private side of the <a href="http://www.discovery.wisc.edu/">Wisconsin Institutes for Discovery</a> (<abbr><abbr title="Wisconsin Institute for Discovery">WID</abbr></abbr>). “I saw firsthand the enormous risks associated with drug discovery and development. Many projects fail.” Kim will certainly draw on his experiences with the likes of Eli Lilly, Pfizer and Parke-Davis, where high-rolling on billion-dollar drugs was the stuff of everyday experience. His latest venture, to be sure, is also a game of chance: sculpting a program for a private research institute with aspirations of not just doing groundbreaking research, but doing it on a continuum that transcends discovery by shepherding the fruits of the laboratory to the end point of delivery to the commercial world. “It’s a high-risk job,” says Carl Gulbrandsen, managing director of the <a href="http://www.warf.org/">Wisconsin Alumni Research Foundation</a> (<abbr>WARF</abbr>), the private, not-for-profit organization that manages intellectual property on behalf of the university. <acronym title="Wisconsin Alumni Research Foundation">WARF</acronym> and alumni John and Tashia Morgridge are providing the major private funding that makes the new institute possible. An additional $50 million in state support is directed toward the public half of <abbr title="Wisconsin Institute for Discovery">WID</abbr>. “Building something from a blank slate is not an easy task,” Gulbrandsen notes. “But it also is a position of great opportunity. With the risk comes the potential for very high returns.” Many view Kim, “Sang” to friends and acquaintances, as the perfect pilot for the Morgridge Institute. Amiable and soft-spoken, Kim is known for his energy and intellect, his varied occupational experiences, and vast network of contacts. In short, he seems to have all the leadership qualities required to weave disparate academic undertakings — computational science, engineering and biology — into a seamless research tapestry under the Morgridge banner. “Universities are filled with really smart people. But every once in a while you encounter someone who is head and shoulders above the rest,” observes <abbr title="University of Wisconsin">UW</abbr>–Madison engineering physics professor Greg Moses, one of the people who recommended Kim for the job. “He brings together all the different pieces. He walks in all these fields. Any subject you bring up with Sang, he seems to know more about it than anyone else in the room.” Kim is indeed an accomplished academic. Born in Korea and raised in Canada, he received his bachelor’s and master’s degrees from Caltech simultaneously. After obtaining his doctorate from Princeton in 1983, he began his career at <abbr title="University of Wisconsin">UW</abbr>–Madison as an assistant professor and climbed the ranks to a named professorship and chair of what is now the department of chemical and biological engineering. As a professor here, Kim became friends with and established closing working ties with former chancellor John Wiley, who at the time was an administrator at the College of Engineering and who is now the interim director of the public Wisconsin Institute for Discovery. Kim left the university in 1997 to work for major pharmaceutical companies and joined the Purdue faculty in 2003. He is a member of the National Academy of Engineering. His university pedigree gives him the street credentials he’ll need to engage the <abbr title="University of Wisconsin">UW</abbr>–Madison community in ways that match the sweeping vision of the Morgridge Institute and the larger Wisconsin Institutes for Discovery. Kim’s experience set is rounded out through an 18-month stint at the National Science Foundation, where he led the charge to transform the agency’s national science and engineering information technology network into an integrated system better suited to the modern scientific enterprise. “I think we’re fortunate to have him,” says Gulbrandsen. “He has great academic experience. He has government experience. He has worked in industry.” For now, it is Kim’s academic experience and intimate knowledge of the culture of the big research university — and of Wisconsin’s research landscape in particular — that may serve him best. Morgridge, like its sister institute, the public Wisconsin Institute for Discovery, is intended to be bigger than just a building or a research program. The intent is to make both institutes integral parts of the fabric of the university. “The biggest challenge in the short term is managing the expectations in the scientific community,” Kim notes. “The institute appearing on the scene as a new opportunity leads to a lot of expectations, and the university and state budgets make for a very challenging environment.” On the opportunity side of the ledger, says Kim, is the chance to build on an intellectual property model that is the envy of universities everywhere: “Wisconsin and <acronym title="Wisconsin Alumni Research Foundation">WARF</acronym> are viewed as the gold standard for technology transfer. We have an opportunity to take something that’s already been successful and take it to a whole new level.” Art Ellis, a former <abbr title="University of Wisconsin">UW</abbr>–Madison chemistry professor who is now the vice president for research at the University of California, San Diego, and who worked with Kim at the National Science Foundation, says Kim has the background and moxie to forge a new intellectual model in the Morgridge setting. “Sang has a deep understanding of intellectual property and technology transfer that will help him bridge the profound differences in academic, government and corporate cultures,” Ellis says. Kim believes the emerging programmatic structure of Morgridge is the platform that will help the institute, <acronym title="Wisconsin Alumni Research Foundation">WARF</acronym> and the university more effectively capitalize on scientific discovery. Now, the plan for Morgridge calls for a central theme of “discovery to delivery.” The discovery platform will be built around two research strengths of <abbr title="University of Wisconsin">UW</abbr>–Madison, regenerative medicine and virology. The element of delivery, Kim explains, involves a chain of opportunity from the point of discovery to application. “Throughout the discovery-to-delivery chain, there are multiple research opportunities,” he notes. The notion of using stem cells as crucibles for drug discovery, for instance, is one that could be supported by engineering new nanoscale surfaces for culturing cells, and bioinformatics research to help predict efficacy and safety. According to Gulbrandsen, Kim’s six-year tour of duty in the pharmaceutical industry lends itself to the research delivery model envisaged for Morgridge: “Between the orphan drug and the billion dollar drug, there are all these unmet needs,” explains Gulbrandsen. “It could be that universities, or philanthropies, or new companies fill that void.” It may also be filled by new kinds of research institutes, like the Morgridge Institute, which are led by polymaths like Kim. Observers agree that Kim is smart, energetic and creative, oozing big ideas. But they also note that by nature he is a friendly and charming individual, disarming qualities in the political cauldron of a research university. “He has a very good manner,” says Gulbrandsen. “He knows how to get where he wants to go without stepping all over you.” Tue Mar 24 15:29:00 -0500 2009

Tue Mar 24 15:33:42 -0500 2009

4 Devitt Terry trdevitt@wisc.edu 16110 Deep drilling begins for Wisconsin Institutes for Discovery geothermal system Deep drilling begins this week to place 75 bore holes approximately 300 feet below the site of the future Wisconsin Institutes for Discovery, marking another first for the interdisciplinary research building project. Deep drilling begins this week to place 75 bore holes approximately 300 feet below the site of the future <a href="http://www.discovery.wisc.edu/">Wisconsin Institutes for Discovery</a>, marking another first for the interdisciplinary research building project. It is the first research facility on campus to be constructed with a geothermal heating and cooling system. Once the facility opens in fall 2010, the unseen holes sunk deep below the earth's surface will provide an annual 10 percent savings on energy use. More than two-thirds of the funding for the facility under construction on the triangle of land between Campus Drive and the 1300 block of University Avenue comes from private gifts from UW-Madison alumni John and Tashia Morgridge and the <a href="http://www.warf.org/">Wisconsin Alumni Research Foundation</a>. The cost of the underground geothermal system, expected to function for at least 50 years, totals $1.25 million. The deep drilling will be completed by the end of 2009, when the facility housing the private <a href="http://www.morgridgeinstitute.org/">Morgridge Institute for Research</a> and the university's public <a href="http://www.wid.wisc.edu/">Wisconsin Institute for Discovery</a> will qualify for a coveted <a href="http://www.usgbc.org/DisplayPage.aspx?CategoryID=19">Leadership in Energy and Environmental Design</a> (<acronym title="Leadership in Energy and Environmental Design">LEED</acronym>) certification. <div id="story_image_1021" class="inline-content photo span" style="width: 550px;"> <img src="http://www.news.wisc.edu/story_images/0000/1021/bore-hole-locations.jpg" alt="Illustration showing the location of the bore hols around the perimeter of each building" /> This site illustration shows the location of the bore holes 75 bores holes.(Courtesy: Wisconsin Institutes for Discovery.) </div> "The decision to include a geothermal system in the facility design reflects one of the core principles of this project — a commitment to using best practices for sustainable development," says George Austin, building project manager for the Wisconsin Institutes for Discovery. Project engineers expect the geothermal system, designed by Affiliated Engineers of Madison, to provide approximately 300 tons of cooling and heating. This capacity can be used continuously for either heating or cooling the building directly, or for optimizing the building's use of the UW-Madison campus district utilities. <div id="story_image_1023" class="inline-content photo right" style="width: 350px;"> <img src="http://www.news.wisc.edu/story_images/0000/1023/DetailofBores01HR.jpg" alt="Cross-section detail of typical bore hole" /> Diagram of a typical bore hole for the WID site. </div> "Geothermal systems provide heating and cooling for buildings by using the mass and relatively constant temperatures of the earth as either a heat sink or source," says Austin. Subsurface conditions determine the effectiveness of a geothermal system. With its placement between two lakes, Austin says, the site of the Wisconsin Institutes for Discovery, as well as Madison in general, is ideal for this type of sustainable energy system. "With both the prevalence and movement of below ground water, the Wisconsin Institutes for Discovery site possesses exceptional subsurface conductivity for a geothermal system," he says. Each bore serves as a "heat exchanger" to allow the transfer of heat to or from the earth when cooling or heating the building respectively. This heat exchanger is coupled to the building mechanical systems through a heat pump chiller, which uses electrically powered compressor technology to balance a portion of the building's internal load. The heat exchanger uses the geothermal heat sink to make up the difference between the building's internal heat gain and load. In other words, the system reuses the heat that is not needed in one part of the building and distributes it where needed in other parts of the building. Other unique features of the Wisconsin Institutes for Discovery include: <ul> <li>An architectural design specifically intended to facilitate interactions and collaboration between the resident researchers.</li> <li>Easily changeable research laboratories built to accommodate a wide range of research activities and to allow for quick conversion of lab space for uses ranging from synthetic chemistry to developmental biology to computer science. This feature is intended to allow, within the facility itself, maximum collaboration between the various scientific disciplines.</li> <li>Housing within a single facility for a public research institute, the Wisconsin Institute for Discovery that is part of the Graduate School and a private, not-for-profit research institute, the Morgridge Institute for Research. No public money will fund the portion of the facility housing the Morgridge Institute for Research.</li> <li>The addition of teaching laboratories on each research floor for use in introducing students of all ages to the excitement of scientific research.</li> <li>A first-floor public space named the Town Center. Like the rest of the building, this space is designed to accommodate a wide range of activities and will offer a restaurant, coffee shop and soda fountain, as well as space for meetings, symposia, education and quiet reflection. It is designed for researchers from across campus and the general public to mingle and share ideas.</li> <li>A commitment to "green" and sustainable building design and operation and a philosophical approach toward the facility and institutes as living experiments. </li> </ul> In addition to this geothermal system being the first to be used in a research facility at UW-Madison (a residential system was installed during the recent reconstruction of Olin House, the official residence of the UW-Madison chancellor), this installation also demonstrates that such a system can be used effectively on a constricted urban site. The site of the Wisconsin Institutes for Discovery has a very narrow perimeter bordered by busy thoroughfares. The narrowness of the site made this project unique since regulations of the Wisconsin Department of Natural Resources restrict the construction of vertical borefields to the outside of a building's footprint. The Wisconsin Institutes for Discovery is a unique public/private initiative designed under one roof to facilitate interdisciplinary research and breakthrough discoveries to improve human health. Made up of the private Morgridge Institute for Research and the public Wisconsin Institute for Discovery, the new facility will open during the fall of 2010. <h2>Live Web cam views of the site</h2> <a href="http://widmir-se.datn.wisc.edu/view/index.shtml">Southeast</a> <a href="http://widmir-nw.datn.wisc.edu/view/index.shtml ">Northwest</a> Tue Jan 06 09:02:00 -0600 2009

83 Kelly Janet jkelly@warf.org 15591 Executive director named for Morgridge Institute for Research A distinguished researcher from Purdue University with significant private and public sector experience will return to Wisconsin as the executive director of the new Morgridge Institute for Research, part of the twin Wisconsin Institutes for Discovery. A distinguished researcher from Purdue University with significant private and public sector experience will return to Wisconsin as the executive director of the new <a href="http://www.morgridgeinstitute.org/">Morgridge Institute for Research</a>, part of the twin <a href="http://www.discovery.wisc.edu/">Wisconsin Institutes for Discovery</a>. <a href="http://www.morgridgeinstitute.org"> Sangtae (Sang) Kim</a>, who currently serves as the Donald W. Feddersen Distinguished Professor of Mechanical Engineering and Distinguished Professor of Chemical Engineering at Purdue, will begin his duties as leader of the Morgridge Institute on Oct. 1. His extensive resume includes serving the <a href="http://www.nsf.gov/">National Science Foundation</a> (NSF) as director of the division of shared cyberinfrastructure in 2004-2005, while on loan from Purdue University, as well as six years of executive industry experience gained at <a href="http://www.lilly.com/research/index.html">Lilly Research Laboratories</a>, <a href="http://www.pfizer.com/research/">Pfizer Global Research</a> and Development and <a href="http://ttp://www.bioportfolio.com/search/Parke___Davis_Pharmaceutical_Research.html">Parke-Davis Pharmaceutical Research</a>. He joined the UW-Madison faculty in 1983 and served as chair of the <a href="http://www.engr.wisc.edu/che/">Department of Chemical Engineering</a> from 1995-1997. During his tenure at UW-Madison, Kim also was granted a courtesy appointment in the <a href="http://www.cs.wisc.edu/">Department of Computer Sciences</a>. His Ph.D. in chemical and biological engineering from Princeton University in 1983 followed concurrent bachelor's and master's of science degrees from the California Institute of Technology in 1979. In 2001, he was elected a member of the prestigious National Academy of Engineering for his contributions to microhydrodynamics, protein dynamics, and drug discovery through the application of high-performance computing. Carl Gulbrandsen, chair of the Morgridge Institute Board of Trustees, says Sang Kim's wealth of experience managing collaborative and interdisciplinary research projects made him an ideal candidate to lead the private, not-for-profit institute. Set to open in 2010, the Morgridge Institute for Research is part of the $150 million Wisconsin Institutes for Discovery public-private partnership designed to facilitate breakthrough discoveries across the fields of biology, computer science and bioengineering to improve human health. "Throughout his years in academia and industry, Sang has proven himself as a bold thinker and exceptional leader who embraces interdisciplinary research,'' Gulbrandsen says. "This is precisely what's needed as we work to set the stage for world-class collaboration and innovation at the Morgridge Institute. His background makes him the perfect candidate for the executive director position." Gulbrandsen says Kim also has an established reputation for commercializing research and helping entrepreneurs transform university discoveries into successful business ventures. Kim currently serves on the scientific advisory board of Venture Investors of Wisconsin and has personally provided advice and technical support to a number of start-up companies. Among them are Alien Technology, a California maker of radio frequency identification (RFID) tags for inventory tracking; and Indigo Biosystems, a software and information management company spun off from Eli Lilly & Co. in 2004. <a href="http://www.wisgov.state.wi.us/"> Gov. Jim Doyle</a> says Kim's excellent academic credentials coupled with strong industry and government experience will serve the state well. "As leader of the Morgridge Institute, Sang Kim will ensure that discoveries in the lab move quickly to the public as treatments and cures," Doyle says. "In the process, the people of Wisconsin will benefit from new jobs and a stronger economy." UW-Madison <a href="http://www.chancellor.wisc.edu/">Chancellor Carolyn "Biddy'' Martin</a> says the vision of the Wisconsin Institutes for Discovery, comprised of twin institutes — one public and one private — is to leverage the best of the public with the best of the private to help keep the university competitive. "The Morgidge Institute, and the university as a whole, will be well served by Sang Kim's unique talents and experience," Martin says. "We also believe he will prove a major asset as the university works to attract and retain faculty members of the very highest caliber." Former UW-Madison Chancellor <a href="http://www.chancellor.wisc.edu/">John Wiley</a>, who has been selected to serve as interim director of the public side of the twin institutes, the Wisconsin Institute for Discovery, says he looks forward to working with Kim, a fellow engineer. "The twin institutes have the potential to be transformational for the university and the entire state of Wisconsin," Wiley says. "I can think of no one more appropriate to lead the Morgridge Institute than Sang Kim." "From his earliest days on campus, in 1983, Sang exemplified precisely the kind of scholar we hope to recruit to the Wisconsin Institutes for Discovery. He was an intellectual leader who was widely respected and sought out by others as a consultant and collaborator. He had a remarkable ability to identify and solve problems having deep and wide implications in multiple fields and disciplines. He was a visionary in seeing those implications and pursuing them," adds Wiley. "And he was literally revered by his students. His contributions to the interdisciplinary Materials Science Program, which I chaired at that time, were and are legendary. It will be a great pleasure and honor to work with Sang again and make sure these institutes are launched in a way that maximizes their potential." As part of the research agenda at Morgridge, Kim's initial work is expected to focus on the establishment of a "center of excellence" for scientific informational technology. Earlier this year, regenerative biology was identified as another thrust area of the Morgridge Institute with the appointment of stem cell pioneer Dr. James Thomson as the first of several scientific directors. Made possible by a $50 million gift from <a href="http://www.discovery.wisc.edu/about/donors.php">John and Tashia Morgridge</a> matched by funding from the Wisconsin Alumni Research Foundation and state of Wisconsin, the Morgridge Institute for Research will leverage the best of a great public university with the flexibility and resources of a world-class private research institute. The building that will house the Morgridge Institute for Research and Wisconsin Institute for Discovery, located on the 1300 block of University Avenue, is expected to serve as a vibrant hub of cross-campus interdisciplinary research. Thu Sep 11 00:00:00 -0500 2008

83 Kelly Janet jkelly@warf.org